Intelligence / Retatrutide

Retatrutide

Under Review
Triple Agonist (GLP-1/GIP/Glucagon)
Schedule
S4
Under Review
Enforcement
Monitoring
Medium Risk
Providers
2
Access: Emerging
Key Facts
Schedule 4 - Prescription Only
Triple GLP-1/GIP/Glucagon receptor agonist
Not yet TGA-approved
Phase 3 trials ongoing globally
Grey market supply emerging in Australia

Overview

Retatrutide is a novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. It is not yet TGA-approved and remains in Phase 3 clinical trials globally. Grey market supply has emerged in Australia.

Australian Scheduling

Schedule 4 (Prescription Only). Not yet TGA-approved or ARTG-listed. Under active regulatory monitoring. Grey market supply is under increasing scrutiny.

Access Pathway

Very limited legal prescription access through 2 identified providers. Most Australian supply is currently through grey market channels, which carries significant regulatory and quality risk.

Regulatory Notice

For informational purposes only. TGA scheduling may change without notice. All Schedule 4 peptides require a valid prescription from a registered Australian medical practitioner. This site does not sell, supply, or facilitate access to therapeutic goods. Data compiled from TGA SUSMP, public provider directories, and publicly available review platforms.

News & Updates20 items
Medical Treatments for Obesity: What Does the Future Have in Store?
J Clin Endocrinol Metab14 July 2026
Retatrutide fact check: Has a man died after taking the unapproved weight loss jab?
BMJ9 July 2026
Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis
BMJ8 July 2026
Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats
Behav Brain Res1 July 2026
Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials
High Blood Press Cardiovasc Prev29 June 2026
Illegal peptide warnings intensify amid acute liver toxicity
RACGP newsGP22 June 2026
Warning issued over counterfeit weight-loss drugs labelled as retatrutide
ABC News19 June 2026
Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus: a network meta-analysis based on clinical trials
Frontiers in Pharmacology18 June 2026
Benefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity: A Living Systematic Review and Network Meta-analysis for the American College of Physicians
Ann Intern Med16 June 2026
GLP-1 agonists in adolescent obesity: a narrative review of single, dual, and triple agonists
Diabetes, Metabolic Syndrome and Obesity12 June 2026
Retatrutide: triple acting jab for type 2 diabetes lowers blood sugar and boosts weight loss, trial reports
BMJ9 June 2026
Lilly's triple agonist, retatrutide, drove substantial improvements in weight, A1C, knee osteoarthritis pain, and obstructive sleep apnea
Eli Lilly7 June 2026
Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.
Current obesity reports6 June 2026
Efficacy and safety of retatrutide in people with type 2 diabetes and inadequate glycaemic control: TRANSCEND-T2D-1 phase 3 trial
The Lancet6 June 2026
Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial
The Lancet6 June 2026
Provide Pre-approval Expanded Access of LY3437943 (Retatrutide) — Eli Lilly
ClinicalTrials.gov5 June 2026
Lilly to present new data on Foundayo, Mounjaro and retatrutide at ADA 86th Scientific Sessions
PR Newswire (Eli Lilly)5 June 2026
GIPR:GCGR co-agonism restores normal weight in obese rodents
Mol Metab1 June 2026
Do GLP-1 Receptor Agonists Sabotage Fat Grafts? : A Scoping Review of GLP-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer
Aesthet Surg J1 June 2026
A hydrophobic tag-assisted liquid-phase strategy for the synthesis of retatrutide
Organic Letters1 June 2026

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