Intelligence / Retatrutide

Retatrutide

Under Review
Triple Agonist (GLP-1/GIP/Glucagon)
Schedule
S4
Under Review
Enforcement
Monitoring
Medium Risk
Providers
2
Access: Emerging
Key Facts
Schedule 4 - Prescription Only
Triple GLP-1/GIP/Glucagon receptor agonist
Not yet TGA-approved
Phase 3 trials ongoing globally
Grey market supply emerging in Australia

Overview

Retatrutide is a novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. It is not yet TGA-approved and remains in Phase 3 clinical trials globally. Grey market supply has emerged in Australia.

Australian Scheduling

Schedule 4 (Prescription Only). Not yet TGA-approved or ARTG-listed. Under active regulatory monitoring. Grey market supply is under increasing scrutiny.

Access Pathway

Very limited legal prescription access through 2 identified providers. Most Australian supply is currently through grey market channels, which carries significant regulatory and quality risk.

Regulatory Notice

For informational purposes only. TGA scheduling may change without notice. All Schedule 4 peptides require a valid prescription from a registered Australian medical practitioner. This site does not sell, supply, or facilitate access to therapeutic goods. Data compiled from TGA SUSMP, public provider directories, and publicly available review platforms.

News & Updates20 items
Do GLP-1 Receptor Agonists Sabotage Fat Grafts? : A Scoping Review of GLP-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer
Aesthet Surg J1 June 2026
GIPR:GCGR co-agonism restores normal weight in obese rodents
Mol Metab1 June 2026
A Hydrophobic Tag-Assisted Liquid-Phase Strategy for the Synthesis of Retatrutide
Org Lett1 June 2026
Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease
Nephrol Dial Transplant29 May 2026
Dysesthesia associated with GLP-1 agonist therapies: data-mining analysis and literature review
Eur J Clin Pharmacol22 May 2026
Evolution of incretin-based therapies: From GLP-1 monotherapy to dual and triple agonists: A new era in metabolic therapy.
The Indian journal of medical research21 May 2026
Diabetes Mellitus and Stroke: Pathophysiological Connections and Therapeutic Potential of GLP-1 and GLP-1/GIP Receptor Agonists.
Pharmaceutics19 May 2026
Kynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation.
Nature communications19 May 2026
Metabolic Dysfunction-Associated Steatotic Liver Disease and Incretin Receptor Agonists: A Metabolic Approach to Halting Liver Disease Progression.
Medicina (Kaunas, Lithuania)18 May 2026
A retrospective audit of weight loss and health outcomes following bariatric surgery at a tertiary public hospital
Obes Res Clin Pract17 May 2026
Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis
Eur J Prev Cardiol15 May 2026
Retatrutide And Lipid And Metabolite Profiles In Participants With Obesity With Or Without Type 2 Diabetes
J Clin Endocrinol Metab14 May 2026
Triple Hormone Receptor Agonism: The Role of Retatrutide in Addressing Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Comprehensive Review
Cardiol Rev11 May 2026
Retatrutide shows significant A1C reduction and weight loss in Phase 3 TRANSCEND-T2D-1 trial
Pharmacy Times15 Apr 2026
Multi-omic profiling reveals Retatrutide alleviates adipose tissue fibrosis via metabolic reprogramming and tissue repair
Diabetology & metabolic syndrome10 Apr 2026
Metabolic inflammation at the adipose-brain axis
Front Physiol10 Apr 2026
Clarivate names retatrutide a defining GLP-1 drug of the next decade, projected $30B sales by 2031
PharmExec8 Apr 2026
Engineered nutrient-stimulated hormonal multi-agonists for precision targeting of obesity and metabolic disorders
Clinical and molecular hepatology1 Apr 2026
Childhood obesity and cardiac risk in youth: Emerging challenges toward 2050
Clinical nutrition ESPEN31 Mar 2026
Retatrutide TRANSCEND-T2D-1 Phase 3 results: up to 2.0% HbA1c reduction and 16.8% weight loss in type 2 diabetes at 40 weeks
RetatrutidePen28 Mar 2026

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